Directions to South Texas Regional Medical Center From:

San Antonio: (approx. 40 miles)
- Highway 16 South to Highway 97 East
or
- Highway 281 South to Highway 97 West
or
- Interstate 37 South to Highway 97 West

Jourdanton: (approx. 1 mile)
- Highway 97 East

Pleasanton: (approx. 4 miles)
- Highway 97 West

Poteet: (approx. 11 miles)
- Highway 16 South to Highway 97 East

Floresville: (approx 28 miles)
- Highway 97 West

Devine: (approx. 29 miles)
- Highway 173 South East to Highway 16 South
- Highway 16 South to Highway 97 East

Tilden: (approx. 33 miles)
- Highway 16 North to Highway 97 East

Pearsall: (approx. 38 miles)
- Highway 140 East to Highway 97 North East (in Charlotte)

Three Rivers: (approx 44 miles)
- Highway 281 North to Highway 97 West